Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations

   Annamarie E Bustion, Renuka R Nayak ... Katherine S Pollard

   Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

   Wenxin Zhang, Taki Nishimura ... Sharon A Tooze

   cis-membrane insertion of human ATG8 N-terminus facilitates autophagosome membrane expansion independent of autophagic cargo.
3. 1. Biochemistry and Chemical Biology

   Nuclear bodies protect phase separated proteins from degradation in stressed proteome

   Kwan Ho Jung, Jiarui Sun ... Xin Zhang
4. 1. Biochemistry and Chemical Biology

   An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

   Tim Aguirre, Sarah Hostachy ... Dorothea Fiedler
5. 1. Biochemistry and Chemical Biology

   Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

   Benjamin R. Duewell, Naomi E. Wilson ... Scott D. Hansen
6. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

   Lina Sagert, Christian Winter ... Robert Tampé
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand

   Maura Greiser, Mariusz Karbowski ... Liron Boyman

   A novel signaling system in heart mitochondria in which the byproduct of energy metabolism, CO₂/bicarbonate, acts as the primary signal to tune mitochondrial ATP production while keeping energy supply in tight synchronization with energy consumption.
8. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses

   Jinyang Wang, Yaxin Wen ... Qinxi Li
9. 1. Biochemistry and Chemical Biology

   Ribozyme activity modulates the physical properties of RNA–peptide coacervates

   Kristian Kyle Le Vay, Elia Salibi ... Hannes Mutschler

   The physical properties of model coacervate protocells are modulated by the activity of an RNA ligase ribozyme, which confers resistance to growth, surface wetting, and material exchange, establishing a link between RNA sequence and protocell phenotype.
10. 1. Biochemistry and Chemical Biology

    Phase separation-mediated actin bundling by the postsynaptic density condensates

    Xudong Chen, Bowen Jia ... Mingjie Zhang