Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Computational and Systems Biology

    Is tumor mutational burden predictive of response to immunotherapy?

    Carino Gurjao, Dina Tsukrov ... Leonid A. Mirny
    1. Cancer Biology

    Precision RNAi using synthetic shRNAmir target sites

    Thomas Hoffmann, Alexandra Hörmann ... Ralph A. Neumüller
    1. Cancer Biology

    MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

    Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe
    Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

    Juan J Apiz Saab, Lindsey N Dzierozynski ... Alexander Muir
    Analysis of the tumor microenvironment reveals that pancreatic tumors experience metabolic stress caused by immune cell degradation of the amino acid arginine, and that pancreatic cancers cope by synthesizing arginine to provide access this amino acid despite low tumor availability.
    1. Cancer Biology

    Arginase 1 is a key driver of immune suppression in pancreatic cancer

    Rosa E Menjivar, Zeribe C Nwosu ... Marina Pasca di Magliano
    Deletion of Arginase 1 in myeloid cells delays tumor formation in pancreatic cancer.
    1. Cancer Biology

    The CD73 immune checkpoint promotes tumor cell metabolic fitness

    David Allard, Isabelle Cousineau ... John Stagg
    Targeting CD73 not only enhances anti-tumor immunity but also disrupts tumor cell metabolism and hinders poly ADP ribose polymerase (PARP) activity, thus unveiling novel opportunities for combination cancer treatments.

Senior editors

  1. Wafik S El-Deiry
    Brown University, United States
  2. Eduardo Franco
    McGill University, Canada
  3. Erica Golemis
    Fox Chase Cancer Center, United States
  4. See more editors