Cancer Biology

Latest articles

1. 1. Cancer Biology

   Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

   Wayne Croft, Hayden Pearce ... Paul Moss
2. 1. Cancer Biology
   2. Genetics and Genomics

   Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

   Robbin A. Nameki, Heidi Chang ... Kate Lawrenson
3. 1. Cancer Biology
   2. Computational and Systems Biology

   Is tumor mutational burden predictive of response to immunotherapy?

   Carino Gurjao, Dina Tsukrov ... Leonid A. Mirny
4. 1. Cancer Biology

   Precision RNAi using synthetic shRNAmir target sites

   Thomas Hoffmann, Alexandra Hörmann ... Ralph A. Neumüller
5. 1. Cancer Biology
   2. Structural Biology and Molecular Biophysics

   Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

   Jean-Philippe Defour, Emilie Leroy ... Stefan N Constantinescu
6. 1. Cancer Biology

   MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

   Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe

   Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.
7. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

   Juan J Apiz Saab, Lindsey N Dzierozynski ... Alexander Muir

   Analysis of the tumor microenvironment reveals that pancreatic tumors experience metabolic stress caused by immune cell degradation of the amino acid arginine, and that pancreatic cancers cope by synthesizing arginine to provide access this amino acid despite low tumor availability.
8. 1. Cancer Biology

   Arginase 1 is a key driver of immune suppression in pancreatic cancer

   Rosa E Menjivar, Zeribe C Nwosu ... Marina Pasca di Magliano

   Deletion of Arginase 1 in myeloid cells delays tumor formation in pancreatic cancer.
9. 1. Cancer Biology

   The CD73 immune checkpoint promotes tumor cell metabolic fitness

   David Allard, Isabelle Cousineau ... John Stagg

   Targeting CD73 not only enhances anti-tumor immunity but also disrupts tumor cell metabolism and hinders poly ADP ribose polymerase (PARP) activity, thus unveiling novel opportunities for combination cancer treatments.
10. 1. Cancer Biology
    2. Immunology and Inflammation

    Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

    Brandon H. Hayes, Mai Wang ... Dennis E. Discher