Genetics and Genomics

Latest articles

1. 1. Evolutionary Biology
   2. Genetics and Genomics

   Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

   David A Murphy, Eyal Elyashiv ... Guy Sella

   Background selection is shown to be the dominant mode of linked selection in humans, with marked effects on diversity levels throughout autosomes.
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

   Anil Kumar Vijjamarri, Xiao Niu ... Alan G Hinnebusch

   The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.
3. 1. Genetics and Genomics
   2. Neuroscience

   Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms

   Yiqiao Zheng, Chi Sun ... Shiming Chen
4. 1. Cancer Biology
   2. Genetics and Genomics

   Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

   Robbin A. Nameki, Heidi Chang ... Kate Lawrenson
5. 1. Developmental Biology
   2. Genetics and Genomics

   Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line

   Mahdi Moradi Marjaneh, Edwin P Kirk ... Richard P Harvey

   A high-resolution picture of genetic complexity and network perturbations underlying cardiac inter-atrial septal dysmorphology associated with patent foramen ovale, a common human congenital anomaly, using quantitative trait locus mapping, genome sequencing, and transcriptomics in a mouse model.
6. 1. Genetics and Genomics

   Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations

   M Elise Lauterbur, Maria Izabel A Cavassim ... Ilan Gronau

   Stdpopsim, a framework for generating realistic chromosome-scale simulations, is expanded to facilitate simulations for non-model species, resulting in insights into how such simulations should be designed.
7. 1. Genetics and Genomics
   2. Immunology and Inflammation

   A critical region of A20 unveiled by missense TNFAIP3 variations that lead to autoinflammation

   Elma El Khouri, Farah Diab ... Irina Giurgea

   Enhanced proteasomal degradation of TNFAIP3 proteins carrying missense variations is one of the pathophysiological mechanisms underlying HA20.
8. 1. Genetics and Genomics

   Sibling Similarity Can Reveal Key Insights Into Genetic Architecture

   Tade Souaiaia, Hei Man Wu ... Paul O’Reilly
9. 1. Evolutionary Biology
   2. Genetics and Genomics

   Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

   Wen-Jie Xu, Chenglong Zhu ... Kun Wang
10. 1. Genetics and Genomics
    2. Immunology and Inflammation

    Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cells

    Alexandru-Ioan Voda, Kristina Correa ... Luke Jostins-Dean