Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    TCR-pMHC complex formation triggers CD3 dynamics

    Floris J. van Eerden, Alrahman Aalaa Sherif ... Daron M. Standley
    1. Immunology and Inflammation

    Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches

    Takuma Asahi, Shinya Abe ... Koichi Ikuta
    Interleukin 15-producing microenvironments in the fetal and adult liver foster a type 1 innate lymphoid cell lineage with intrinsic cytotoxicity mediated through cytotoxic granules that are expressed under their steady state, unlike conventional natural killer cells with stimulation-dependent cytotoxicity.
    1. Immunology and Inflammation

    Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

    Carlos Castrillon, Lea Simoni ... Michael C Carroll
    1. Genetics and Genomics
    2. Immunology and Inflammation

    A critical region of A20 unveiled by missense TNFAIP3 variations that lead to autoinflammation

    Elma El Khouri, Farah Diab ... Irina Giurgea
    Enhanced proteasomal degradation of TNFAIP3 proteins carrying missense variations is one of the pathophysiological mechanisms underlying HA20.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3

    Rémi Porte, Rita Silva-Gomes ... Alberto Mantovani
    Long Pentaxin 3 is highly expressed by non-hematopoietic cells during Streptococcus pneumoniae invasive infections and regulates polymorphonuclear neutrophils' recruitment through interaction with P-selectin which damps inflammation-associated tissue damage and pneumococcal systemic dissemination.
    1. Immunology and Inflammation

    Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling

    Rafaela M Guimarães, Conceição E Aníbal-Silva ... Thiago M Cunha
    CX3CR1-signaling in sensory ganglia macrophages mediates their proliferation/activation, as well as the production of pro-inflammatory mediators that contribute to neuropathic pain.
    1. Microbiology and Infectious Disease
    2. Immunology and Inflammation

    Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli

    Sharon A McGrath-Morrow, Jarrett Venezia ... Alan L Scott
    A pre-clinical model of E. coli pneumonia reveals attenuated dynamics of MHCII-expressing mononuclear cells in neonatal lung associated with elevated susceptibility to bacterial pneumonia.

Senior editors

  1. Betty Diamond
    The Feinstein Institute for Medical Research, United States
  2. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  3. Satyajit Rath
    Indian Institute of Science Education and Research (IISER), Pune, India
  4. See more editors