Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   TCR-pMHC complex formation triggers CD3 dynamics

   Floris J. van Eerden, Alrahman Aalaa Sherif ... Daron M. Standley
2. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

   Lina Sagert, Christian Winter ... Robert Tampé
3. 1. Immunology and Inflammation

   Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches

   Takuma Asahi, Shinya Abe ... Koichi Ikuta

   Interleukin 15-producing microenvironments in the fetal and adult liver foster a type 1 innate lymphoid cell lineage with intrinsic cytotoxicity mediated through cytotoxic granules that are expressed under their steady state, unlike conventional natural killer cells with stimulation-dependent cytotoxicity.
4. 1. Immunology and Inflammation

   Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

   Carlos Castrillon, Lea Simoni ... Michael C Carroll
5. 1. Genetics and Genomics
   2. Immunology and Inflammation

   A critical region of A20 unveiled by missense TNFAIP3 variations that lead to autoinflammation

   Elma El Khouri, Farah Diab ... Irina Giurgea

   Enhanced proteasomal degradation of TNFAIP3 proteins carrying missense variations is one of the pathophysiological mechanisms underlying HA20.
6. 1. Immunology and Inflammation

   Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

   Eva Morgun, Jennifer Zhu ... Chyung-Ru Wang
7. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cells

   Alexandru-Ioan Voda, Kristina Correa ... Luke Jostins-Dean
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3

   Rémi Porte, Rita Silva-Gomes ... Alberto Mantovani

   Long Pentaxin 3 is highly expressed by non-hematopoietic cells during Streptococcus pneumoniae invasive infections and regulates polymorphonuclear neutrophils' recruitment through interaction with P-selectin which damps inflammation-associated tissue damage and pneumococcal systemic dissemination.
9. 1. Immunology and Inflammation

   Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling

   Rafaela M Guimarães, Conceição E Aníbal-Silva ... Thiago M Cunha

   CX3CR1-signaling in sensory ganglia macrophages mediates their proliferation/activation, as well as the production of pro-inflammatory mediators that contribute to neuropathic pain.
10. 1. Microbiology and Infectious Disease
    2. Immunology and Inflammation

    Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli

    Sharon A McGrath-Morrow, Jarrett Venezia ... Alan L Scott

    A pre-clinical model of E. coli pneumonia reveals attenuated dynamics of MHCII-expressing mononuclear cells in neonatal lung associated with elevated susceptibility to bacterial pneumonia.