Latest research

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations

    Annamarie E Bustion, Renuka R Nayak ... Katherine S Pollard
    Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.
    1. Cell Biology

    An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo

    Peter H Lee, Michael Anaya ... Kai Zinn
    The cell-surface protein Stranded at second is a targeting ligand for extracellular vesicles that can deliver dArc1 capsids containing dArc1 mRNA to distant cells in vivo.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

    Wenxin Zhang, Taki Nishimura ... Sharon A Tooze
    cis-membrane insertion of human ATG8 N-terminus facilitates autophagosome membrane expansion independent of autophagic cargo.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

    David A Murphy, Eyal Elyashiv ... Guy Sella
    Background selection is shown to be the dominant mode of linked selection in humans, with marked effects on diversity levels throughout autosomes.
    1. Neuroscience

    Rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning

    Krzysztof H. Olszyński, Rafał Polowy ... Robert K. Filipkowski
    1. Neuroscience

    MotorNet: a Python toolbox for controlling differentiable biomechanical effectors with artificial neural networks

    Olivier Codol, Jonathan A. Michaels ... Paul L. Gribble
    1. Medicine

    An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

    Luyang Cao, Lixiang Ma ... Jingsong Xu