Insights

Insight articles are related to original research papers in eLife and explain why the results reported in the paper are significant in a given field of research. Insight articles are commissioned by eLife staff.

Latest articles

    1. Cell Biology

    Skeletal Muscle: The origin of T-tubules

    Callum J Quinn, Katharine M Dibb
    Ring-like structures made up of caveolae appear to drive the development of membrane invaginations called T-tubules which are important for muscle contraction.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Brain Development: The dangers of rubella virus

    Ekaterina Epifanova, Laurent Nguyen
    The rubella virus can interfere with fetal brain development by infecting immune cells called microglia during pregnancy.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Microbiology and Infectious Disease

    Parasite Communication: Learning the language of pathogens

    Izadora Volpato Rossi, Marcel Ivan Ramirez
    Parasites can use extracellular vesicles and cellular projections called cytonemes to communicate with one another.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Cell Biology
    2. Physics of Living Systems

    Cell Size: Putting scaling laws on a physical foundation

    Yiyang Ye, Jie Lin
    As a cell changes size during the cell cycle, why does its density remain constant?
    Insight
    Formats available:
    • HTML
    • PDF
    1. Evolutionary Biology

    Palaeontology: Sexual dimorphism in dinosaurs

    Stella A Ludwig, Roy E Smith, Nizar Ibrahim
    Studying fossils from a mass-mortality event reveals evidence for sexual dimorphism and, unusually, equal numbers of males and females in a herd of dinosaurs.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Nuclear Receptors: Alternative activation

    Kristen Young, Sean Fanning
    A detailed study of the orphan receptor Nurr1, a regulator implicated in neurodegenerative diseases, reveals a new way for ligands to control their transcriptional activity.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Chromosomes and Gene Expression

    Gene Expression: Listen and learn

    Sarah E London
    In songbirds, deafening leads to changes in gene expression which have now been mapped at the single-cell level across the neural circuit involved in song production.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Microbiology and Infectious Disease

    Growth: Inside help from the microbiome

    Sneha Agrawal, Nichole A Broderick
    Elucidating the role of one of the proteins produced by Lactiplantibacillus plantarum reveals a new molecule that allows this gut bacterium to support the development of fruit fly larvae.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Drug Discovery: Decoding the mechanisms of allostery

    Saif Khan, Cornelius Gati
    A complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Physics of Living Systems

    Vasculature: Exploring the dynamics of vascular adaptation

    Thomas S Shimizu, E Toby Kiers, Howard A Stone
    A combination of in toto imaging and theory suggests a new mechanism for the remodeling of veins in vascular networks.
    Insight
    Formats available:
    • HTML
    • PDF