Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations

    Annamarie E Bustion, Renuka R Nayak ... Katherine S Pollard
    Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.
    1. Cell Biology

    An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo

    Peter H Lee, Michael Anaya ... Kai Zinn
    The cell-surface protein Stranded at second is a targeting ligand for extracellular vesicles that can deliver dArc1 capsids containing dArc1 mRNA to distant cells in vivo.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

    Wenxin Zhang, Taki Nishimura ... Sharon A Tooze
    cis-membrane insertion of human ATG8 N-terminus facilitates autophagosome membrane expansion independent of autophagic cargo.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

    David A Murphy, Eyal Elyashiv ... Guy Sella
    Background selection is shown to be the dominant mode of linked selection in humans, with marked effects on diversity levels throughout autosomes.
    1. Neuroscience

    Targeted memory reactivation in human REM sleep elicits detectable reactivation

    Mahmoud EA Abdellahi, Anne CM Koopman ... Penelope A Lewis
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons

    Théodore Grenier, Jessika Consuegra ... François Leulier
    Bacterial ribosomal and transfer RNAs are symbiotic clues sensed by host general control nonderepressible 2 to support Drosophila systemic growth.
    1. Cell Biology
    2. Computational and Systems Biology

    An in silico FSHD muscle fiber for modeling DUX4 dynamics and predicting the impact of therapy

    Matthew V Cowley, Johanna Pruller ... Christopher RS Banerji
    Mathematical and experimental characterization of DUX4 expression dynamics in facioscapulohumeral muscular dystrophy muscle fibers, provides insights into pathology and open-source tools for in silico investigation of anti-DUX4 therapy.