Structural Biology and Molecular Biophysics

Latest articles

1. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   TCR-pMHC complex formation triggers CD3 dynamics

   Floris J. van Eerden, Alrahman Aalaa Sherif ... Daron M. Standley
2. 1. Structural Biology and Molecular Biophysics

   Mechanistic insights into robust cardiac I_Ks potassium channel activation by aromatic polyunsaturated fatty acid analogues

   Briana M Bohannon, Jessica J Jowais ... H Peter Larsson
3. 1. Structural Biology and Molecular Biophysics

   Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

   David N Tippett, Colum Breen ... Raimund Dutzler

   The structural and functional characterization of SLC26A6 provides greater understanding of coupled versus uncoupled transport processes for the SLC26 transporter family.
4. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

   Huan Wang, Syed R A Rizvi ... Shozeb Haider
5. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Exploring the K⁺ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

   Solveig G. Schmidt, Andreas Nygaard ... Claus J. Loland
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand

   Maura Greiser, Mariusz Karbowski ... Liron Boyman

   A novel signaling system in heart mitochondria in which the byproduct of energy metabolism, CO₂/bicarbonate, acts as the primary signal to tune mitochondrial ATP production while keeping energy supply in tight synchronization with energy consumption.
7. 1. Structural Biology and Molecular Biophysics

   Interplay between VSD, pore and membrane lipids in electromechanical coupling in HCN channels

   Ahmad Elbahnsi, John Cowgill ... Lucie Delemotte
8. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Systematic analysis of the molecular and biophysical properties of key DNA damage response factors

   Joshua R Heyza, Mariia Mikhova ... Jens C Schmidt
9. 1. Cancer Biology
   2. Structural Biology and Molecular Biophysics

   Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

   Jean-Philippe Defour, Emilie Leroy ... Stefan N Constantinescu
10. 1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Rapid protein stability prediction using deep learning representations

    Lasse M Blaabjerg, Maher M Kassem ... Kresten Lindorff-Larsen

    RaSP is a method for making rapid and accurate predictions of changes in protein stability that enabled us to calculate ~300 million stability changes for nearly all possible single amino acid changes in the human proteome.